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KMID : 0352720090330040324
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Journal of Ginseng Research
2009 Volume.33 No. 4 p.324 ~ p.329
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Regulatory Effect of Ginsenosides Rh1 on Monocytic U937 Cell Adhesion
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Kim Byung-Hun
Cho Jae-Youl
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Abstract
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Cell-cell adhesion managed by various adhesion molecules is known to be one of pathophysiological phenomena found in numerous immunological diseases such as rheumatoid arthritis and allergic diseases. In this study, we examined the regulatory role of ginsenosides (G)- Rh1, reported to display anti-inflammatory and anti-allergic effects, on CD29-mediated cell adhesion. G-Rh1 significantly suppressed U937 cell-cell adhesion mediated by CD29 but not CD43. It also blocked U937 cell-fibronectin adhesion, mediated by activated CD29, up to 30%. In agreement, this compound also significantly decreased the surface level of CD29 but not CD43 as well as other costimulatory molecules such as CD69, CD80, and CD86. Therefore, these results suggest that G-Rh1 may have inhibitory function on CD29-mediated cell adhesion events, probably contributing to its anti-inflammatory and anti-allergic activities.
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KEYWORD
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ginsenoside Rh1, cell-cell adhesion, CD29, monocytic cell, U937 cell
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